Multifunctional Nanomagnetic Scavengers Restore Immune Homeostasis in Rodent Bacteremia Models

The work led by Sung Jin Park and Seyong Kwon has been published in Small on September 7th, 2022 (online). We reported human blood cell-coated superparamagnetic nanovesicles (MNVs) that capture an extreme range of pathogens in whole blood. Rat bacteremia models lethally infected with carbapenem resistant (CR) E. coli and methicillin resistant S. aureus (MRSA) were fully recovered by the extracorporeal treatment using our MNVs particles. Other pathogens, including human fecal bacteria, RSV, CMV, SARS-CoV-2, and their variants, were successfully eradicated from the whole blood. We are currently making significant efforts to bring this technology toward preclinical and clinical validations.